The below cookies help Matomo in its purpose. This includes attempts to identify hypothalamic genes with specific function for glucose sensing. An additional specific objective is to promote our knowledge on glucose sensing systems and their role in the control of energy homeostasis and body weight. Its purpose is to identify individual clients behind a shared IP address and apply security settings on a per-client basis. Privacy Preferences I Agree.

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It further promotes endothelial cell dysfunction towards the appearance of pre-atherosclerotic lesions and overt atherosclerosis accompanied with cardiac complications.

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Advanced knowledge on this endocrine activity under normal bj-0602 pathological conditions is of key importance for developing new strategies to combat major metabolic diseases related to adipose tissue dysfunction. Its usage help us improve Users Experience by tracking each visitor anonymously. Additional aims are to identify variants of genes coding for adipose secretory products, an important step towards defining new biomarkers of the metabolic syndrome.

The differentiation between effects of locally produced cytokines and adipose-tissue derived cytokines may provide better understanding of beta cell dysfunction and may lead to selective approaches to ameliorate the harmful consequences of each. Specific aims are to identify the molecular basis of this gender-related difference and its impact for obesity and type 2 diabetes.

One aim is related to the elucidation of the bn-0602 between neuroendocrine dysregulation and adipose tissue secretory function and inflammation.

By clicking “I Agree” you are allowing COST website to store cookies on your devices to enhance user experience and monitor website usage. Elucidation of adipose tissue secretory function Adipose tissue is considered as a major endocrine organ.

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Adipose cell size is critically related to glucose tolerance and insulin sensitivity. Furthermore, it is known that hypothalamic systems involved in energy balance and appetite regulation are subject to profound gender differences.


To reach the overall goal of this project, a multidisciplinary network will address the following secondary objectives: This approach is driven by the hypothesis that adipose tissue is critically involved in transducing environmental and nutritional factors into endogenous signals which mediate insulin resistance, vascular complications, beta cell dysfunction and the manifestation b-0602 type 2 diabetes.

Bm0-602 provides detailed reports on the website and its visitors. Assessment of the relationship between cytokines, inflammation and vascular dysfunction and skeletal muscle insulin resistance The combined effects of peripheral insulin resistance and vascular disease is devastating as it promotes uncontrolled hyperglycemia and damaging effects on peripheral organs and beta cells.

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BM – Adipose Tissue: This knowledge will help to improve therapeutic measures and patient stratification. A second main objective is to define the molecular targets involved in the initiation of skeletal muscle insulin resistance.

Attempts will also be made to uncover potential synergistic interactions between cytokines, hyperglycemia and increased levels of free fatty acids.

Finally, attempts will be made to better understand plasticity of adipose tissue, which may represent a new approach to prevention of the metabolic syndrome.

Therefore, a major goal is to understand how hypertrophy of adipose cells leads to impaired lipid storage capacity, impaired adipogenesis and systemic insulin resistance. Specifically, different neuroendocrine systems cortisol axis, sex hormones, renin-angiotensin system will be addressed and their impact for the aetiology of the metabolic syndrome will be evaluated.

Its purpose is bm-06002 identify individual clients behind a shared IP address and apply security settings on a per-client basis. An additional specific objective is to promote our knowledge on glucose sensing systems and their role in the control of energy homeostasis and body weight.

Action BM – COST

Progressive damage and deterioration of these cells lead to decreased beta cell mass, bbm-0602 insulin biosynthesis and impaired glucose-regulated insulin secretion. Matomo is a web analytics software platform. Therefore, the main objective of this b-0602 task is to comprehensively explore the regulation of adipose tissue secretory function, the origin of secretory products within the tissue, the actions of these products at the local and peripheral levels and the pathophysiological relevance for humans.


Additional objectives include the identification bm0-602 novel bm-06002 products and the investigation of the pathophysiological role of the adipose tissue and its secretory products in human or animal models of the metabolic syndrome and type 2 diabetes.

Gluco-lipotoxcity, islet inflammation, beta cell dysfunction and type 2 diabetes Multifactorial stressful stimuli are harmful to beta cells and affect their survival and function. Privacy Preferences I Agree. Detailed understanding of the molecular mechanisms that lead to beta cell apoptosis and dysfunction is essential for developing new strategies to prevent or delay the onset of type 2 diabetes. This knowledge is essential for developing novel drug and life-style intervention strategies.

Additional attempts will be made to define the secretory activity of different fat depots and their impact for the aetiology of the metabolic syndrome. Another important objective is to investigate and validate a current hypothesis that some harmful proinflammatory cytokines are produced by beta cells or islets exposed to hyperglycemia or fatty acids.

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To give you the best possible experience, this website uses cookies. Description Bm-002 Management Committee Description The main objective of the Action is to advance our knowledge on the pathogenesis and prevention of obesity and the specific role of adipose tissue in the development of the metabolic syndrome.

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